{"id":25461,"date":"2026-08-07T12:12:00","date_gmt":"2026-08-07T10:12:00","guid":{"rendered":"https:\/\/ibsal.es\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\/"},"modified":"2026-08-07T12:12:22","modified_gmt":"2026-08-07T10:12:22","slug":"researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma","status":"publish","type":"post","link":"https:\/\/ibsal.es\/en\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\/","title":{"rendered":"Researchers Identify Abnormalities in the Regulation of the p53 Protein That Affect the Prognosis of Patients with Multiple Myeloma"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">A research team from the CIBER Cancer Division (<a href=\"https:\/\/www.ciberonc.es\/\">CIBERONC<\/a>) at the <a href=\"https:\/\/www.saludcastillayleon.es\/CASalamanca\/es\">Salamanca University Healthcare<\/a><a href=\"https:\/\/ibsal.es\/en\/\" data-type=\"link\" data-id=\"ibsal.es\">Complex\u2013Salamanca Biomedical Research Institute (IBSAL)<\/a> and the <a href=\"https:\/\/www.cicancer.org\/\">Cancer Research Center<\/a> (USAL-CSIC), led by hematologist <a href=\"https:\/\/ibsal.portalinvestigacion.com\/investigadores\/484\">Norma C. Guti\u00e9rrez<\/a>, has<strong> identified alterations in the regulation of post-translational modifications of the p53 protein that may help predict the clinical course of patients with multiple myeloma,<\/strong> one of the most common blood cancers. The results, published in the journal <em>*Blood Cancer Journal*<\/em>, demonstrate that certain <strong>post-translational modifications of the p53 protein<\/strong> <strong>provide prognostic information independently of alterations in the <em>TP53<\/em> gene<\/strong>, which is considered one of the main markers of poor prognosis in this disease. <\/p>\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p class=\"wp-block-paragraph\">The p53 protein plays an essential role in protecting cells from DNA damage and in preventing tumor development. Although alterations in the <em>TP53<\/em> gene can prevent this protein from functioning properly, its activity can also be affected by post-translational modifications\u2014small chemical changes that regulate its stability and its ability to respond to cellular damage. <\/p>\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p class=\"wp-block-paragraph\">In this study, the research team analyzed samples collected at the time of diagnosis from <strong>127 patients with multiple myeloma who were treated according to the GEM2012 protocol of the Spanish Myeloma Group<\/strong>. Using a highly sensitive technique called <strong>capillary nanoimmunoassay<\/strong>, they quantified four post-translational modifications of the p53 protein\u2014three phosphorylations and one acetylation\u2014that are involved in regulating its activity. <\/p>\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p class=\"wp-block-paragraph\"><em>&#8220;The results revealed considerable variability among patients. In addition, those with biallelic inactivation of the TP53 gene had significantly lower levels of some of these modifications <\/em>&#8221; explains <a href=\"https:\/\/ibsal.portalinvestigacion.com\/investigadores\/719\">Elizabeta A. Rojas<\/a>, the study&#8217;s lead author and a CIBERONC researcher at CIC\/IBSAL. Furthermore, lower p53 phosphorylation was associated with a higher risk of disease progression. <\/p>\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p class=\"wp-block-paragraph\">The collaborative study, involving several groups from CIBERONC, also analyzed other components of the <strong>DNA damage response<\/strong>, such as the <strong>\u03b3H2AX<\/strong> marker <strong>, the Chk2 kinase, and the PP1A and PP2A-C phosphatases<\/strong>. Alterations in these proteins suggest that the mechanisms regulating the phosphorylation status of p53 may be compromised in some patients, contributing to the loss of its function, even in the absence of genetic alterations in <em>TP53<\/em>. <\/p>\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p class=\"wp-block-paragraph\"><strong><em>&#8220;This is the first study to systematically analyze post-translational modifications of the p53 protein in a large cohort of patients with multiple myeloma. The findings show that the regulation of p53 plays a significant role in the clinical course of the disease and suggest that the evaluation of these modifications could complement genetic analysis of TP53 to improve prognostic stratification of patients,&#8221; <\/em><\/strong>concludes the research team.<\/p>\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p class=\"wp-block-paragraph\">The study received public funding from the Carlos III Health Institute (PI23\/00319) and the Castilla y Le\u00f3n Regional Health Authority (GRS3044\/A1\/2024). In addition, Elizabeta A. Rojas has received support from the Spanish Foundation for Hematology and Hemotherapy (FEHH) as part of the FEHH\u2019s 2024 call for research grants. <\/p>\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p class=\"wp-block-paragraph\"><strong>Article reference:<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">Rojas EA, Crist\u00f3bal-Vargas S, Becerro-Recio D, De Ram\u00f3n C, Cuadrado M, Isidro I, Misiewicz-Krzeminska I, Mart\u00ednez-L\u00f3pez J, Oriol A, Rosi\u00f1ol L, Lahuerta JJ, San Miguel JF, Mateos MV, Corchete LA, Guti\u00e9rrez NC.  <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42469225\/\" target=\"_blank\" rel=\"noreferrer noopener\">Study of Post-Translational Modifications of p53 in Multiple Myeloma. Blood Cancer J. <\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42469225\/\" target=\"_blank\" rel=\"noreferrer noopener\"> <\/a>July 17, 2026. doi: 10.1038\/s41408-026-01568-x. Published online ahead of print. PMID: 42469225.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A research team from the CIBER Cancer Division (CIBERONC) at the Salamanca University HealthcareComplex\u2013Salamanca Biomedical Research Institute (IBSAL) and the Cancer Research Center (USAL-CSIC), led by hematologist Norma C. Guti\u00e9rrez, [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":25462,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"footnotes":"","_members_access_role":[],"_members_access_error":""},"categories":[238,239,229],"tags":[242],"class_list":["post-25461","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-news-highlights","category-uncategorized","tag-cancer-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.12 (Yoast SEO v28.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Researchers Identify Abnormalities in the Regulation of the p53 Protein That Affect the Prognosis of Patients with Multiple Myeloma | IBSAL<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibsal.es\/en\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Researchers Identify Abnormalities in the Regulation of the p53 Protein That Affect the Prognosis of Patients with Multiple Myeloma\" \/>\n<meta property=\"og:description\" content=\"A research team from the CIBER Cancer Division (CIBERONC) at the Salamanca University HealthcareComplex\u2013Salamanca Biomedical Research Institute (IBSAL) and the Cancer Research Center (USAL-CSIC), led by hematologist Norma C. Guti\u00e9rrez, [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibsal.es\/en\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\/\" \/>\n<meta property=\"og:site_name\" content=\"IBSAL\" \/>\n<meta property=\"article:published_time\" content=\"2026-08-07T10:12:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-08-07T10:12:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibsal.es\/wp-content\/uploads\/2026\/08\/Foto-de-grupo-e1785840151587.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2000\" \/>\n\t<meta property=\"og:image:height\" content=\"1127\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Sergi\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sergi\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibsal.es\\\/en\\\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibsal.es\\\/en\\\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\\\/\"},\"author\":{\"name\":\"Sergi\",\"@id\":\"https:\\\/\\\/ibsal.es\\\/en\\\/#\\\/schema\\\/person\\\/34ba5672452d5f86b117e6cb49a6bb97\"},\"headline\":\"Researchers Identify Abnormalities in the Regulation of the p53 Protein That Affect the Prognosis of Patients with Multiple Myeloma\",\"datePublished\":\"2026-08-07T10:12:00+00:00\",\"dateModified\":\"2026-08-07T10:12:22+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibsal.es\\\/en\\\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\\\/\"},\"wordCount\":547,\"image\":{\"@id\":\"https:\\\/\\\/ibsal.es\\\/en\\\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibsal.es\\\/wp-content\\\/uploads\\\/2026\\\/08\\\/Foto-de-grupo-e1785840151587.jpg\",\"keywords\":[\"Cancer\"],\"articleSection\":[\"News\",\"News highlights\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibsal.es\\\/en\\\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\\\/\",\"url\":\"https:\\\/\\\/ibsal.es\\\/en\\\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\\\/\",\"name\":\"Researchers Identify Abnormalities in the Regulation of the p53 Protein That Affect the Prognosis of Patients with Multiple Myeloma | IBSAL\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibsal.es\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/ibsal.es\\\/en\\\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/ibsal.es\\\/en\\\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibsal.es\\\/wp-content\\\/uploads\\\/2026\\\/08\\\/Foto-de-grupo-e1785840151587.jpg\",\"datePublished\":\"2026-08-07T10:12:00+00:00\",\"dateModified\":\"2026-08-07T10:12:22+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/ibsal.es\\\/en\\\/#\\\/schema\\\/person\\\/34ba5672452d5f86b117e6cb49a6bb97\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/ibsal.es\\\/en\\\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/ibsal.es\\\/en\\\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/ibsal.es\\\/en\\\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\\\/#primaryimage\",\"url\":\"https:\\\/\\\/ibsal.es\\\/wp-content\\\/uploads\\\/2026\\\/08\\\/Foto-de-grupo-e1785840151587.jpg\",\"contentUrl\":\"https:\\\/\\\/ibsal.es\\\/wp-content\\\/uploads\\\/2026\\\/08\\\/Foto-de-grupo-e1785840151587.jpg\",\"width\":2000,\"height\":1127},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/ibsal.es\\\/en\\\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\\\/\\\/ibsal.es\\\/en\\\/institute-of-biomedical-research-of-salamanca\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Researchers Identify Abnormalities in the Regulation of the p53 Protein That Affect the Prognosis of Patients with Multiple Myeloma\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/ibsal.es\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/ibsal.es\\\/en\\\/\",\"name\":\"IBSAL\",\"description\":\"Benchmarks in translational research in biomedicine in Castilla y Le\u00f3n\",\"alternateName\":\"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/ibsal.es\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/ibsal.es\\\/en\\\/#\\\/schema\\\/person\\\/34ba5672452d5f86b117e6cb49a6bb97\",\"name\":\"Sergi\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/528ac3b73275e0b7aaacef0c293ace2a4935f7e6f58f8b31465b2faf9ae5ed56?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/528ac3b73275e0b7aaacef0c293ace2a4935f7e6f58f8b31465b2faf9ae5ed56?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/528ac3b73275e0b7aaacef0c293ace2a4935f7e6f58f8b31465b2faf9ae5ed56?s=96&d=mm&r=g\",\"caption\":\"Sergi\"}}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Researchers Identify Abnormalities in the Regulation of the p53 Protein That Affect the Prognosis of Patients with Multiple Myeloma | IBSAL","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ibsal.es\/en\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\/","og_locale":"en_US","og_type":"article","og_title":"Researchers Identify Abnormalities in the Regulation of the p53 Protein That Affect the Prognosis of Patients with Multiple Myeloma","og_description":"A research team from the CIBER Cancer Division (CIBERONC) at the Salamanca University HealthcareComplex\u2013Salamanca Biomedical Research Institute (IBSAL) and the Cancer Research Center (USAL-CSIC), led by hematologist Norma C. Guti\u00e9rrez, [&hellip;]","og_url":"https:\/\/ibsal.es\/en\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\/","og_site_name":"IBSAL","article_published_time":"2026-08-07T10:12:00+00:00","article_modified_time":"2026-08-07T10:12:22+00:00","og_image":[{"width":2000,"height":1127,"url":"https:\/\/ibsal.es\/wp-content\/uploads\/2026\/08\/Foto-de-grupo-e1785840151587.jpg","type":"image\/jpeg"}],"author":"Sergi","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Sergi","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/ibsal.es\/en\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\/#article","isPartOf":{"@id":"https:\/\/ibsal.es\/en\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\/"},"author":{"name":"Sergi","@id":"https:\/\/ibsal.es\/en\/#\/schema\/person\/34ba5672452d5f86b117e6cb49a6bb97"},"headline":"Researchers Identify Abnormalities in the Regulation of the p53 Protein That Affect the Prognosis of Patients with Multiple Myeloma","datePublished":"2026-08-07T10:12:00+00:00","dateModified":"2026-08-07T10:12:22+00:00","mainEntityOfPage":{"@id":"https:\/\/ibsal.es\/en\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\/"},"wordCount":547,"image":{"@id":"https:\/\/ibsal.es\/en\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\/#primaryimage"},"thumbnailUrl":"https:\/\/ibsal.es\/wp-content\/uploads\/2026\/08\/Foto-de-grupo-e1785840151587.jpg","keywords":["Cancer"],"articleSection":["News","News highlights"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/ibsal.es\/en\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\/","url":"https:\/\/ibsal.es\/en\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\/","name":"Researchers Identify Abnormalities in the Regulation of the p53 Protein That Affect the Prognosis of Patients with Multiple Myeloma | IBSAL","isPartOf":{"@id":"https:\/\/ibsal.es\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/ibsal.es\/en\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\/#primaryimage"},"image":{"@id":"https:\/\/ibsal.es\/en\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\/#primaryimage"},"thumbnailUrl":"https:\/\/ibsal.es\/wp-content\/uploads\/2026\/08\/Foto-de-grupo-e1785840151587.jpg","datePublished":"2026-08-07T10:12:00+00:00","dateModified":"2026-08-07T10:12:22+00:00","author":{"@id":"https:\/\/ibsal.es\/en\/#\/schema\/person\/34ba5672452d5f86b117e6cb49a6bb97"},"breadcrumb":{"@id":"https:\/\/ibsal.es\/en\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ibsal.es\/en\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/ibsal.es\/en\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\/#primaryimage","url":"https:\/\/ibsal.es\/wp-content\/uploads\/2026\/08\/Foto-de-grupo-e1785840151587.jpg","contentUrl":"https:\/\/ibsal.es\/wp-content\/uploads\/2026\/08\/Foto-de-grupo-e1785840151587.jpg","width":2000,"height":1127},{"@type":"BreadcrumbList","@id":"https:\/\/ibsal.es\/en\/researchers-identify-abnormalities-in-the-regulation-of-the-p53-protein-that-affect-the-prognosis-of-patients-with-multiple-myeloma\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Portada","item":"https:\/\/ibsal.es\/en\/institute-of-biomedical-research-of-salamanca\/"},{"@type":"ListItem","position":2,"name":"Researchers Identify Abnormalities in the Regulation of the p53 Protein That Affect the Prognosis of Patients with Multiple Myeloma"}]},{"@type":"WebSite","@id":"https:\/\/ibsal.es\/en\/#website","url":"https:\/\/ibsal.es\/en\/","name":"IBSAL","description":"Benchmarks in translational research in biomedicine in Castilla y Le\u00f3n","alternateName":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ibsal.es\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/ibsal.es\/en\/#\/schema\/person\/34ba5672452d5f86b117e6cb49a6bb97","name":"Sergi","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/528ac3b73275e0b7aaacef0c293ace2a4935f7e6f58f8b31465b2faf9ae5ed56?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/528ac3b73275e0b7aaacef0c293ace2a4935f7e6f58f8b31465b2faf9ae5ed56?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/528ac3b73275e0b7aaacef0c293ace2a4935f7e6f58f8b31465b2faf9ae5ed56?s=96&d=mm&r=g","caption":"Sergi"}}]}},"_links":{"self":[{"href":"https:\/\/ibsal.es\/en\/wp-json\/wp\/v2\/posts\/25461","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ibsal.es\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibsal.es\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibsal.es\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/ibsal.es\/en\/wp-json\/wp\/v2\/comments?post=25461"}],"version-history":[{"count":1,"href":"https:\/\/ibsal.es\/en\/wp-json\/wp\/v2\/posts\/25461\/revisions"}],"predecessor-version":[{"id":25463,"href":"https:\/\/ibsal.es\/en\/wp-json\/wp\/v2\/posts\/25461\/revisions\/25463"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibsal.es\/en\/wp-json\/wp\/v2\/media\/25462"}],"wp:attachment":[{"href":"https:\/\/ibsal.es\/en\/wp-json\/wp\/v2\/media?parent=25461"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibsal.es\/en\/wp-json\/wp\/v2\/categories?post=25461"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibsal.es\/en\/wp-json\/wp\/v2\/tags?post=25461"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}