{"id":24394,"date":"2026-05-12T11:04:39","date_gmt":"2026-05-12T09:04:39","guid":{"rendered":"https:\/\/ibsal.es\/liver-moon-project-studying-the-impact-of-night-work-on-health\/"},"modified":"2026-08-04T12:54:39","modified_gmt":"2026-08-04T10:54:39","slug":"liver-moon-project-studying-the-impact-of-night-work-on-health","status":"publish","type":"post","link":"https:\/\/ibsal.es\/en\/liver-moon-project-studying-the-impact-of-night-work-on-health\/","title":{"rendered":"LIVER-MOON Project: Studying the Impact of Night Work on Health"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Several CIBER research groups are leading the <strong>LIVER-MOON<\/strong> project, an initiative that seeks <strong>to understand how night work and disruptions to the circadian rhythm can affect health and increase the risk of disease.<\/strong><\/p>\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p class=\"wp-block-paragraph\">Coordinated by M\u00aa Luz Mart\u00ednez Chantar, a researcher in the Liver and Digestive Diseases area (CIBEREHD) at CIC BioGune, and Juan P. Bola\u00f1os, a researcher in the Frailty and Healthy Aging area (CIBERFES) and at the Salamanca Biomedical Research Institute (IBSAL) at the Institute of Functional Biology and Genomics (IBFG, USAL-CSIC), this project is one of four selected in the First Call for CIBER Interdisciplinary Projects and has been awarded 222,000 euros for a two-year period. The project also involves the CIBERDEM group led by Montserrat Romero de Pablos, the CIBERNED group led by Jos\u00e9 Luis Cantero Lorente, and the CIBEROBN group led by Francisco Jos\u00e9 Ortega Delgado. <\/p>\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"735\" height=\"325\" src=\"https:\/\/ibsal.es\/wp-content\/uploads\/2026\/05\/image-1.png\" alt=\"\" class=\"wp-image-22694\" srcset=\"https:\/\/ibsal.es\/wp-content\/uploads\/2026\/05\/image-1.png 735w, https:\/\/ibsal.es\/wp-content\/uploads\/2026\/05\/image-1-300x133.png 300w\" sizes=\"(max-width: 735px) 100vw, 735px\" \/><\/figure>\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<h3 class=\"wp-block-heading\"><strong>Hydrogen sulfide<\/strong><\/h3>\n\n<p class=\"wp-block-paragraph\"><strong>The study centers on a key molecule: hydrogen sulfide (H\u2082S)<\/strong>. The project is based on the hypothesis that disruptions in circadian rhythms could destabilize its production, leading to an exacerbation of oxidative stress and an increased risk of liver, brain, and adipose tissue dysfunction, as well as associated metabolic disorders. <\/p>\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p class=\"wp-block-paragraph\">In this regard, and given the limited information available on this subject, LIVER-MOON  <strong>It will adopt a multidisciplinary and innovative approach to provide new data on the effects of circadian rhythm disruption on H\u2082S production and its impact on health. To this end, mouse models and human samples will be used. <\/strong><\/p>\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<h3 class=\"wp-block-heading\"><strong>Diet as a Potential Protective Factor<\/strong><\/h3>\n\n<p class=\"wp-block-paragraph\">The research team proposes mitigating the systemic adverse effects of night work <strong>through a dietary approach that adjusts the levels of plant proteins, thereby promoting the production of hydrogen sulfide<\/strong>. These interventions will be carried out both over short periods of time\u2014three weeks\u2014and in chronic conditions lasting three months. <\/p>\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p class=\"wp-block-paragraph\">In addition, in the same mouse models, compounds capable of releasing H\u2082S in a controlled manner\u2014such as SG-1002 and AP39\u2014will be administered orally. At the same time, the opposite effect\u2014that is, the inhibition of the enzymes responsible for H\u2082S production (CBS, CSE, and 3MPST)\u2014will also be studied in order to clarify the role of H\u2082S under different conditions and to improve our understanding of oxidative stress and liver and brain function. <\/p>\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<h3 class=\"wp-block-heading\"><strong>Validation in a population with altered circadian rhythms<\/strong><\/h3>\n\n<p class=\"wp-block-paragraph\">To validate and compare the results observed in mouse models, H\u2082S production and associated metabolites will be measured in an observational study involving healthy middle-aged volunteers with disrupted circadian rhythms, as well as older adults at risk for Alzheimer\u2019s disease who have sleep disorders.<\/p>\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p class=\"wp-block-paragraph\">\u201cWith LIVER-MOON, we aim to understand how disruptions to the circadian rhythm affect key metabolic processes and whether it is possible to intervene\u2014for example, through diet or by modulating hydrogen sulfide\u2014to reduce their effects on health,\u201d says M\u00aa Luz, the project coordinator.<\/p>\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p class=\"wp-block-paragraph\">The results of this study could lay the groundwork for the development of new prevention strategies aimed at mitigating the effects of night work.<\/p>\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p class=\"wp-block-paragraph\">Source of the news: <a href=\"https:\/\/www.ciberisciii.es\/noticias\/proyecto-liver-moon-estudiando-el-impacto-del-trabajo-nocturno-en-la-salud\">CIBER<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Several CIBER research groups are leading the LIVER-MOON project, an initiative that seeks to understand how night work and disruptions to the circadian rhythm can affect health and increase the 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