Although reactive oxygen species (ROS) have traditionally been associated with a harmful effect on the cell, the importance of ROS for the regulation of cellular signalling and genetic expression has recently been exposed. The group lead by Dr Angel Hernández Hernández is interested in the role of ROS as second messengers in hematopoietic differentiation. Our research shows that the generation of ROS by the NADPH oxidase family is required for megakaryocytic differentiation, so we are now focusing on its mechanism. In addition, as tumour cells have a higher level of ROS than normal cells, an interesting antitumour strategy would be to modulate said levels. To that effect we are currently studying the possible use of NADPH oxidase as therapeutic targets in leukemia.


Research team:

  • CANC10
  • JefeGrupo
  • Default
  • Title
  • Date
  • Random
    • CANC10
    • JefeGrupo

    Ángel Hernández Hernández

    Universidad de Salamanca

Research team:
  • Violeta García Hernández
  • Carla Ijurko Valeta
  • Marcial Llanillo Ortega
  • Alejandro Pérez Fernández
  • Rodrigo Prieto Bermejo
  • Marta Romo González
Research associates:
  • --
 

Research focus:

  • Role of reactive oxygen species in hematopoiesis.
  • Use of NADPH oxidase as therapeutic targets in cancer.

Publications

Click to access


Projects

Click to access


News

We use cookies to improve our website and your experience when using it. Cookies used for the essential operation of the site have already been set. To find out more about the cookies we use and how to delete them, see our Privacy Policy.

I accept cookies from this site